Alactic base excess predicts the use of renal replacement therapy in patients with septic shock

Abstract Background Alactic base excess (ABE) is a novel biomarker that estimates the renal capability of handling acid–base alterations during sepsis. Hence, aim this study was to evaluate use ABE predict replacement therapy (RRT) in patients with septic shock. Methods A total 164 admitted intensive care units diagnosis shock according third international consensus on sepsis and (Sepsis-3) were included. This retrospective, single center, conducted between January 1, 2016, December 31, 2020. The individuals stratified who did [ n = 68] or not 96] receive RRT. diagnostic performed variables for classification into required RRT evaluated by receiver operating characteristic (ROC) analysis area under curve (AUC) calculated. Univariate multivariate logistic regression models used identify risk factors Results median age 59 years female sex (51.8%) predominated. (odds ratio [OR] 1.2270, [95% confidence interval [CI] 1.0453–1.4403], p 0.0124) urea (OR 1.0114, CI 1.0053–1.0176], 0.0002) associated HCO 3 − 0.6967, 0.5771–0.8410], protective factor (AUC 0.649, < 0.0008), 0.729, 0.0001), 0.76, 0.0001) had cutoff point ≤ 5.7 mmol/L, 19.36 mmol/L > 75 mg/dL, respectively. Conclusion Although low risk, are independent